intensive, motor, personalized, anywhere, challenging training for premanifest and early SpinoCerebellar Ataxia

intensive, motor, personalized, anywhere, challenging training for premanifest and early SpinoCerebellar Ataxia - impact-p/reSCA

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00039679

Enrollment

Registered

2026-03-20

Start date

2026-04-15

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinocerebellar Ataxia

Interventions

Group 1: We will assess the effectiveness of a 6-week intensive individualized home training protocol programme for participants in the premanifest or early stage of spinocerebellar ataxia. . The trai

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: First-degree relatives of an index patient with a known Spinocerebellar ataxia SCA 1, 2, 3, 6, or 27B mutation and a score of <8 on the Scale for the Assessment and Rating of Ataxia (SARA).

Exclusion criteria

Exclusion criteria: Lack of informed consent, severe visual or hearing impairment, cognitive impairment, orthopedic limitations that impair mobility

Design outcomes

Primary

Measure	Time frame
Primary outcome is a composite measure of static and dynamic balance in sensor-based analysis of complex stance tasks and turning movements . Participants will be examined four times: six weeks before intervention during standard care (A1), immediately before the first training session (A2), after the six-week home training period (A3) as well as a follow-up period of 6 months (A4). We will use digital gait assessment using wearable sensors in a motion lab and in patients' real life to capture and quantify motor improvements apart from exercises.	—

Measure

Time frame

Primary outcome is a composite measure of static and dynamic balance in sensor-based analysis of complex stance tasks and turning movements . Participants will be examined four times: six weeks before intervention during standard care (A1), immediately before the first training session (A2), after the six-week home training period (A3) as well as a follow-up period of 6 months (A4). We will use digital gait assessment using wearable sensors in a motion lab and in patients' real life to capture and quantify motor improvements apart from exercises.

—

Secondary

Measure	Time frame
Secondary outcomes: Intervention-induced changes measured by clinical scores, digital sensor measures, patient/observer reported and molecular outcome measures. • Clinical ataxia severity scores SARA, FARS-E • patient-reported outcomes: ABC, GAS and PGI-S motor • Neurofilament light chain (NfL) concentration as a fluid biomarker of neurodegeneration	—

Countries

Germany

Contacts

Public ContactWinfried Ilg

Hertie Institut für klinische Hirnforschung

winfried.ilg@uni-tuebingen.de+4970712989125

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026