Personalized Rehabilitation through AI Development – Identification of Molecular, Physiological, and Psychological Phenotypes to Optimize Individualized Therapeutic Approaches

Personalized Rehabilitation through AI Development – Identification of Molecular, Physiological, and Psychological Phenotypes to Optimize Individualized Therapeutic Approaches - INNOVARE

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00039676

Enrollment

400

Registered

2026-04-27

Start date

2026-03-17

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.-, I21.- / I22.-, R52.- I25 I21 I22 R52

Interventions

Group 1: Standard rehabilitation according to clinical guidelines without additional personalization

serves as control condition and for phenotype identification. Group 2: Personalized rehabilitation tailored to individual molecular, physiological, and psychological profiles derived from prior data a

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diagnosed coronary artery disease (CAD), history of myocardial infarction, or chronic pain (e.g., chronic low back pain) Participation in a rehabilitation program Willingness to participate in the study and provision of written informed consent Willingness to regularly participate in the prescribed rehabilitation measures Sufficient proficiency in the German language Ability to complete questionnaires and to use digital technologies (e.g., smartphone-based applications)

Exclusion criteria

Exclusion criteria: Severe physical limitations that preclude participation in rehabilitation measures (e.g., advanced neurodegenerative diseases) Participation in another clinical study or any condition that precludes study participation Pregnancy Inability to achieve the primary endpoint

Design outcomes

Primary

Measure	Time frame
Change in health-related quality of life (WHOQOL total score) from T1 to T6 between standard rehabilitation and personalized rehabilitation (16 weeks after discharge)	—

Secondary

Measure	Time frame
Secondary clinical endpoints: WHOQOL subscales (physical, psychological) Work Ability Index (WAI) Secondary mechanistic endpoints: Inflammatory markers (e.g., IL-6) Mitochondrial function (TFAM/TFB2M interaction, ATP levels) Other endpoints: Treatment adherence EMA-based parameters (e.g., fatigue, pain, etc.)	—

Countries

Germany

Contacts

Public ContactBjörn Koos

Knappschaft Kliniken Universitätsklinikum Bochum

bjoern.koos@rub.de0234-2993001

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026