Analysis of the perioperative administration of antibiotics in patients with a history of penicillin allergy

Analysis of the perioperative administration of antibiotics in patients with a history of penicillin allergy - One-year-PEN-FAST

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039644

Enrollment

1488

Registered

2026-05-05

Start date

2026-05-05

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Z88.0

Interventions

Group 1: Patients who reported a beta-lactam allergy and received perioperative antibiotic prophylaxis between 1 December, 2023, and 30 November, 2024 will be retrospectively assessed for the antibiot

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All adult patients who underwent surgery between 1 December 2023 and 30 November 2025, who reported an allergy to penicillin and/or aminopenicillin as part of their pre-operative preparation, and who received perioperative antimicrobial prophylaxis will be screened.

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Percentage of patients who, despite a history of allergy to penicillin and/or aminopenicillin, received a ß-lactam antibiotic perioperatively.	—

Secondary

Measure	Time frame
-Frequency of allergic reactions and their severity, positive tryptase test -Frequency of postoperative complications (C. difficile infection, wound infection) -Use of reserve antibiotics since the introduction of the PEN-FAST score compared with the same period last year	—

Countries

Germany

Contacts

Public ContactMaren Keller

Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Leipzig AöR

maren.keller@medizin.uni-leipzig.de+493419717700

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026