Proteomic Profiling of Biological Tissue Response to Orthodontic Force Application – pilot study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039628

Enrollment

Registered

2026-03-31

Start date

2026-04-03

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K07.4

Interventions

Group 1: Behandlung mit herausnehmbarer kieferorthopädischer Apparatur (Aligner) Treatment with removable orthodontic appliances (aligners) Erhebungen im Rahmen der Studie: T0: 1 Woche vor Behandlung

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Indication for orthodontic treatment with aligners or multibracket appliances Complete medical history, as well as clinical and radiographic assessment

Exclusion criteria

Exclusion criteria: Smoker Medication use Systemic diseases (acute or chronic) Oral pathologies (e.g. active caries, gingivitis, or periodontitis, salivary gland disorders)

Design outcomes

Primary

Measure	Time frame
Type and characterization of proteins, as well as quantification/number of proteins and their changes depending on mechanical loading. The salivary proteome will be compared with the proteome of gingival crevicular fluid (GCF).	—

Secondary

Measure	Time frame
Investigation of the dependence of the primary endpoints on age, sex, treatment type (Group 1/Group 2), approximal plaque index (API), and sulcus bleeding index (SBI).	—

Countries

Germany

Contacts

Public ContactHisham Sabbagh

LMU Klinikum

hisham.sabbagh@med.uni-muenchen.de+49 89 4400 53231

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026