New ICU-acquired infections in the context of continuous renal replacement therapy
Conditions
Interventions
Group 1: Scheduled dialysis filter change during continuous renal replacement therapy at 36 ± 3 hours
Group 2: Standard of care with scheduled dialysis filter change during continuous renal replacemen
Sponsors
Universitätsklinikum Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Critcally ill patients with severe AKI consistent with KDIGO stage 3 and an absolute indication for CRRT 2. Written consent form from the patient or legal representative or authorized representative or emergency inclusion
Exclusion criteria
Exclusion criteria: 1. End-stage kidney disease or chronic dialysis dependence 2. Chronic kidney disease with eGFR<20ml/min/1.73m2 3. Prior kidney transplant 4. Prior renal replacement therapy during the index admission before randomization 5. Glomerulonephritis, interstitial nephritis, vasculitis 6. Patients on immunosuppression (above the cushing threshold) 7. Patients with chronic inflammatory diseases (e.g. arthritis, HIV with a CD4 count of < 0.05 x 10E/l) 8. Do-not resuscitate order 9. Persons with any kind of dependency on the investigator or employed by the sponsor 10. Patients participating in an interventional study involving measures to influence the immune system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Mean filter lifespan per patient. End of CRRT or at day 30, whatever occurs first. Documented filter change in patient record/dialysis data. 2. Protocol adherence. End of CRRT or at day 30, whatever occurs first. Documented filter change in patient record/dialysis data within a predefined time window (intervention group: 36±3h; control group: 48-72h). | — |
Secondary
| Measure | Time frame |
|---|---|
| Newly intensive care unit-associated acquired infection up to day 30. Up to 48 hours after ICU discharge or at day 30, whatever occurs first. Documented in patient record and cultural proven. | — |
Countries
Germany
Contacts
Public ContactAlexander Zarbock
Universitätsklinikum Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Outcome results
None listed