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Personalized Adolescent Therapy using network-informed approaches (PATH): A Proof-of-Concept Study of a Network-Informed Personalized Treatment Approach

Personalized Adolescent Therapy using network-informed approaches (PATH): A Proof-of-Concept Study of a Network-Informed Personalized Treatment Approach - PATH

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00039604
Enrollment
6
Registered
2026-03-17
Start date
2026-03-23
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F00-F99

Interventions

Group 1: This study uses a single-case (N-of-1) design including five adolescent patients with a mental disorder who begin outpatient psychotherapy. The course of these five cases will be systematical

Sponsors

JGU Mainz
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 17 Years

Inclusion criteria

Inclusion criteria: Inclusion is transdiagnostic, meaning that participants are eligible regardless of the specific (suspected) disorder, provided that an indication for outpatient psychotherapy has been established during the initial assessment session. Additional inclusion criteria are sufficient German language proficiency and written informed consent from both the participants and their legal guardians.

Exclusion criteria

Exclusion criteria: Patients will be excluded if they present with acute suicidality or other crisis conditions requiring immediate treatment, manifest psychotic disorders, severe intellectual disability, or significant cognitive or language impairments that would prevent participation in the assessments.

Design outcomes

Primary

MeasureTime frame
The primary outcomes of the study are: 1) the level of psychopathological symptoms, including general psychological distress, depressive symptoms, anxiety symptoms, and aggressive behavior. These outcomes will be assessed using standardized questionnaires completed by adolescents (self-report) and their parents (parent report) (SDQ, PSC-D, PHQ-A, SCARED, RPQ) and 2) changes in the adolescents’ individual symptom networks, assessed using PECAN-CA based on adolescent self-report. Primary outcomes will be assessed at two time points: before the start of psychotherapy (pre-treatment) and immediately after the completion of psychotherapy (post-treatment). In addition, repeated measurements will be conducted during therapy. The individual symptom network will be reassessed using PECAN-CA every five therapy sessions. Furthermore, the severity of individually relevant symptoms will be assessed at each therapy session.

Secondary

MeasureTime frame
At the same assessment time points (pre- and post-treatment), child quality of life (KINDL) and illness perceptions (IPQ-R) will be assessed via adolescent self-report. In addition, feasibility questions regarding the use of symptom networks will be collected during each therapy session. At post-treatment, an additional feasibility questionnaire assessing the acceptability of the personalization approach based on symptom networks will be administered; “In addition, speech samples will be analyzed to investigate whether the prioritized symptoms are reflected in participants’ language use and whether changes in symptomatology over time are mirrored in linguistic features.

Countries

Germany

Contacts

Public ContactFelix Vogel

JGU Mainz

fvogel@uni-mainz.de+49 6131 39 32453

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026