in-vivo bone oxygenation
Conditions
Interventions
Group 1: In healthy volunteers (n = 120), measurements of bone blood flow and oxygenation will be performed using near-infrared spectroscopy (NIRS) with the device PortaMon manufactured by Artinis Med
Sponsors
Universitätsklinikum des Saarlandes/Lehrstuhl für Innovative Implantatentwicklung (Frakturheilung)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age = 18 years (legal adulthood), No injuries, tattoos, or skin alterations at the sites to be examined, Written and oral informed consent (if capable of giving consent)
Exclusion criteria
Exclusion criteria: Inability to provide informed consent, Minority (under 18 years of age), Known pregnancy, Injuries, tattoos, or skin alterations at the sites to be examined
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Oxygenated hemoglobin (O2Hb) 2.Deoxygenated hemoglobin (HHb) 3.Total hemoglobin (tHb) 4.Hemoglobin difference (HbDiff) 5.Tissue Saturation Index (TSI) The device used is the PortaMon near-infrared spectroscopy device by Artinis (continuous wave near-infrared spectroscopy using the modified Lambert-Beer law) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Age 2. Sex 3. BMI 4. Nicotine abuse 5. Alcohol abuse 6. Diabetes 7. Hand grip strength Data collection using a handgrip dynamometer (Kern MAP 130K1, Kern, Balingen, Germany). In addition, participants are weighed using personal scales and their height is measured. Furthermore, participants are interviewed using a structured questionnaire regarding the presence of diabetes mellitus (with or without insulin therapy), nicotine abuse (measured in pack-years), and alcohol consumption (measured in g/week). | — |
Countries
Germany
Contacts
Public ContactBergita Ganse
Universitätsklinikum des Saarlandes/ Lehrstuhl für Innovative Implantatentwicklung ( Frakturheilung)
Outcome results
None listed