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Total Salivary Calcium Dynamics After Brushing with Toothpastes Containing Different Active Ingredients

Total Salivary Calcium Dynamics After Brushing with Toothpastes Containing Different Active Ingredients - Toothpaste Formulations and Salivary Calcium

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00039385
Enrollment
48
Registered
2026-02-18
Start date
2024-04-21
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention

Interventions

Group 1: Determination of calcium levels in saliva (immediately, after 30 minutes, and after 60 minutes) of the participants following a 2-minute application of Lidl Dentalux Triple Protection Fresh G

Sponsors

Universität Witten/Herdecke
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Eligible individuals were in good general and oral health, had at least 20 natural permanent teeth, a gum-stimulated whole salivary flow rate = 0.8 mL/min, and an unstimulated whole salivary flow rate = 0.5 mL/min. Exclusion criteria included pregnancy or breastfeeding; chronic systemic disease or conditions associated with xerostomia; diabetes; known intolerance or hypersensitivity to study materials; antibiotic use at the time of screening or within the preceding two weeks; and use of multivitamin, calcium, or fluoride supplements within seven days prior to the study phase

Exclusion criteria

Exclusion criteria: Dental-related exclusion criteria comprised untreated caries, periodontal disease, or dental treatment during the study period; oral surgery or tooth extraction within six weeks prior to screening; and the presence of oral lesions, sores, or inflammatory conditions.

Design outcomes

Primary

MeasureTime frame
Determination of calcium levels after the use of the three toothpastes in the laboratory; the working hypothesis is that salivary Ca²? levels are elevated when pyrophosphate-containing toothpastes are used.

Countries

Germany

Contacts

Public ContactMozhgan Bizhang

Universität Witten/Herdecke

mozhgan.bizhang@uni-wh.de+49

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026