Prevention
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Eligible individuals were in good general and oral health, had at least 20 natural permanent teeth, a gum-stimulated whole salivary flow rate = 0.8 mL/min, and an unstimulated whole salivary flow rate = 0.5 mL/min. Exclusion criteria included pregnancy or breastfeeding; chronic systemic disease or conditions associated with xerostomia; diabetes; known intolerance or hypersensitivity to study materials; antibiotic use at the time of screening or within the preceding two weeks; and use of multivitamin, calcium, or fluoride supplements within seven days prior to the study phase
Exclusion criteria
Exclusion criteria: Dental-related exclusion criteria comprised untreated caries, periodontal disease, or dental treatment during the study period; oral surgery or tooth extraction within six weeks prior to screening; and the presence of oral lesions, sores, or inflammatory conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of calcium levels after the use of the three toothpastes in the laboratory; the working hypothesis is that salivary Ca²? levels are elevated when pyrophosphate-containing toothpastes are used. | — |
Countries
Germany
Contacts
Universität Witten/Herdecke