The study investigates the rise in blood glucose following sugar intake and its potential modulation by dietary fiber. Pronounced or repeatedly elevated postprandial blood glucose levels are considered a risk factor for the development of metabolic diseases such as type 2 diabetes. The aim of the study is to improve the understanding of preventive nutritional strategies and to examine whether different amounts of dietary fiber contribute to stabilizing blood glucose levels.
Conditions
Interventions
Group 1: Intake of water without chia seeds, followed by a standard oral glucose tolerance test (75 g glucose).
Group 2: Single intake of 10 g chia seeds dissolved in water prior to the oral glucose t
Sponsors
Universitätsklinikum Frankfurt am Main
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Eligible for inclusion are adults (= 18 years) in good general health without known metabolic disorders and with a body mass index between 18.5 and 29.9 kg/m². Participants must be willing to attend all scheduled study visits and provide written informed consent after receiving appropriate information about the study. Adequate German language proficiency is required to ensure full understanding of the study information and questionnaires.
Exclusion criteria
Exclusion criteria: Individuals with known metabolic disorders, particularly diabetes mellitus or impaired glucose tolerance, as well as chronic diseases affecting glucose metabolism or digestion, are excluded from participation. Persons taking medications that influence glucose metabolism, those with known allergies or intolerances to chia seeds or components of the test solutions, pregnant or breastfeeding women, and individuals with acute illnesses at the time of assessment are also excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the postprandial glucose response, defined as the area under the glucose curve (AUC0–120) within 120 minutes following an oral glucose tolerance test, measured using continuous glucose monitoring (CGM) and capillary blood glucose measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include the maximum postprandial glucose concentration and the time to peak within the 120-minute period, subjective satiety, well-being, and gastrointestinal symptoms (assessed using standardized self-report measures), as well as diurnal and nocturnal interstitial glucose profiles during the test days. | — |
Countries
Germany
Contacts
Public ContactTobias Engeroff
Institut für Arbeitsmedizin, Sozialmedizin und Umweltmedizin
Outcome results
None listed