Does buffering with NaHCO3 or TRIS buffer affect blood coagulation? A ROTEM study

Does buffering with NaHCO3 or TRIS buffer affect blood coagulation? A ROTEM study - NaTRIS

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00039357

Enrollment

Registered

2026-02-17

Start date

2025-11-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E87.2

Interventions

Group 1: healthy volunteers A blood sample is taken by puncture. It is divided into 5 parts. The unchanged sample is measured in the ROTEM. In the remaining four samples, acidosis with a pH value of 7

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: No history of coagulation disorders

Exclusion criteria

Exclusion criteria: Lack of consent Known coagulation disorder Use of anticoagulants Myelodysplastic syndrome Existence of guardianship

Design outcomes

Primary

Measure	Time frame
Comparison of measurement results from rotational thromboelastometry before and after buffering	—

Countries

Germany

Contacts

Public ContactGerrit Herpertz

Universitätsklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie

gerrit.herpertz@uol.de+49

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026