Healthy Mothers and their newborn children
Conditions
Interventions
Group 1: Collection of umbilical cord blood and placental tissue from newborns, as well as blood samples from healthy adult donors, followed by the investigation of cellular and molecular differences
Sponsors
Genzentrum der LMU
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Pregnant women: =18 years of age; planned delivery at LMU University Hospital Großhadern; ability to provide informed consent in German or (if offered) English; consent obtained prior to delivery. Newborns: born to the same participant; umbilical cord blood collection after clamping and cutting of the umbilical cord; no study-related intervention performed on the child. Adult controls: =18 years of age; not pregnant; self-reported “healthy” status; ability to provide informed consent; written informed consent.
Exclusion criteria
Exclusion criteria: Minor pregnant women; lack of capacity to provide informed consent; absence of written informed consent. Emergency or precipitous deliveries with medical priority where providing study information is not feasible; severe obstetric complications requiring priority of acute medical care. Acute febrile infections/neutropenia; known relevant immunodeficiencies; systemic immunosuppression (e.g., >10 mg prednisolone equivalent for >14 days); known active autoimmune disease or inflammatory systemic disease. Known highly contagious or notifiable infections with special hygiene requirements (e.g., open tuberculosis, hemorrhagic fevers; standard BSL-2 infections will be processed according to hygiene standards but may be excluded based on resource or safety considerations). Anticoagulation with high bleeding risk or severe anemia (<9 g/dL hemoglobin) for optional maternal blood sampling. For adult controls additionally: current pregnancy; chronic inflammatory or autoimmune disease; ongoing immunosuppressive therapy; acute infection (<14 days).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aim of the study: Mechanistic understanding of perinatal Inflammation and Interferon pathways | — |
Countries
Germany
Contacts
Public ContactJonathan Bohlen
Genzentrum der LMU
Outcome results
None listed