Defining a physiological upper reference limit for the hepatic doppler perfusion Index (DPI) in healthy adults and its dependence on physiological conditions: in rest, postexercise and postprandial, with simultaneously measurement of GLP-2 (Glukagon-like Peptide 2)

Defining a physiological upper reference limit for the hepatic doppler perfusion Index (DPI) in healthy adults and its dependence on physiological conditions: in rest, postexercise and postprandial, with simultaneously measurement of GLP-2 (Glukagon-like Peptide 2) - NormDPI Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039291

Enrollment

Registered

2026-03-20

Start date

2025-11-03

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Doppler perfusion index (DPI) quantifies the ratio of arterial to total hepatic blood flow and reflects a key aspect of hepatic hemodynamic balance. Alterations of this balance are characteristic of various liver diseases. Glukagon-like peptide-2 (GLP-2) is a key messenger substance in gastrointestinal tract. Yet physiological reference values in healthy individuals, especially in different physiological conditions, are lacking.

Interventions

Group 1: In this prospective, controlled study, 44 healthy adults underwent visceral Doppler ultrasonography under three standardized conditions: fasting/resting, post-exercise, and postprandial resti

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - healthy participants - ability to train on bicycle ergometer - no current medication - no abdominal surgery in the past, except appendectomy

Exclusion criteria

Exclusion criteria: - current medication - significant chronic disease, especially cardiovascular diseases - abdominal surgery in the past, except appendectomy

Design outcomes

Primary

Measure	Time frame
Endpoint is the measurement of (doppler perfusion Index)DPI of liver arteries and portal vein as well as levels of GLP-2 in three diffferent physiological conditions - a physiological basic work. The parameters were measured on day of participation by sonography (3x) and venous blood collection (3x = 30ml). Then freezing the blood samples (- 80°C) and later the anaylisis of GLP-2 in a specialized laboratory. Data ist collected in context of Sonography, and the level of GLP-2 is analyzed in a laboratory.	—

Measure

Time frame

Endpoint is the measurement of (doppler perfusion Index)DPI of liver arteries and portal vein as well as levels of GLP-2 in three diffferent physiological conditions - a physiological basic work. The parameters were measured on day of participation by sonography (3x) and venous blood collection (3x = 30ml). Then freezing the blood samples (- 80°C) and later the anaylisis of GLP-2 in a specialized laboratory. Data ist collected in context of Sonography, and the level of GLP-2 is analyzed in a laboratory.

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Countries

Germany

Contacts

Public ContactChristian Lüders

Klinik am See

christian.lueders@klinikamsee.com004933638780

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Apr 4, 2026