N18.5
Conditions
Interventions
Group 1: First, cognitive performance is assessed at a baseline time point within the first two hours of dialysis. In addition, central and transcranial blood pressure are measured at this time point
Sponsors
Justus Liebig Universität
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: · Patients over the age of 18 · Patients with end-stage renal failure receiving hemodialysis therapy · Informed consent · Agreement to undergo further neuropsychological testing during the course of the study, e.g., after 3 months and 1 year · German as native language (as the neuropsychological testing and training are language-dependent).
Exclusion criteria
Exclusion criteria: · Pre-existing neurological or psychiatric disorders (in particular, history of cerebral infarction, traumatic brain injury, manifest depression, or dementia) that could impair neuropsychological testing. · Patients who are under legal guardianship · Patients who are unable to understand the patient information or who are unable to cooperate mentally due to their general state of health · Insufficient knowledge of the German language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is the neuropsychological outcome influenced by cognitive training (CT)? The question of cognitive performance change is determined a priori in a one-sided manner. Specifically, the following directed hypothesis is to be tested: H0: Under covariance of the preoperative mean z-values, the post-intervention mean z-values of the intervention group (immediately following training) are above the post-intervention mean z-values of the control group. H1: Under covariance of the preoperative mean z-values (postoperative, before training), the postoperative mean z-values of the intervention group (immediately after training) are below/equal to the postoperative mean z-values of the control group. 2. If the training program has a positive effect on the neuropsychological outcome immediately after the intervention, is this effect still detectable 3 months after the operation? | — |
Secondary
| Measure | Time frame |
|---|---|
| • Are only specific cognitive functions affected by the training effect? • Do the risk factors described in Anglo-American literature, such as age, gender, dialysis duration, Kt/V (as a measure of dialysis quality), underlying disease, hypertension, and sleep apnea, interact with the cognitive performance of the patient group examined in Giessen? • Do biochemically recorded parameters of disease-specific comorbidities (anemia, secondary hyperparathyroidism, uremic acidosis, vitamin D deficiency, aluminum levels) interact with the degree of cognitive impairment? • Does the measurement of central blood pressure correlate with possible fluctuations in the measurement of cerebral perfusion? | — |
Countries
Germany
Contacts
Public ContactHristos Karakizlis
Justus Liebig Universität Gießen
Outcome results
None listed