C69-C72
Conditions
Interventions
Group 1: Study arm 1 focuses on preoperative language mapping using transcranial magnetic stimulation (TMS). The mapping is conducted using not only the standard task of object naming but also a newly
Nasreddine et al., 2005), the Berlin Aphasia Score (Tuncer et al., 2021), as well as reaction time measurements during the sentence completion task.
Sponsors
Universitätsklinik für Neurochirurgie, Evangelisches Klinikum Bethel
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Suspected brain tumor (imaging-based suspected diagnosis), clinically assessed relevant risk of postoperative speech disorder
Exclusion criteria
Exclusion criteria: Preoperative language level below the requirements of the language tasks performed, contraindications for transcranial magnetic stimulation (cardiac pacemaker, cochlear implant, intracranial clips)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TMS parameters for the object naming task and sentence completion task are recorded, including the number of errors, error rates, error locations, and types of errors. In addition, as part of preoperative planning, the reconstructability of fiber tracts (based on routine MRI sequences) and their concordance to the TMS-identified sites are assessed. The endpoints of study arm 2 are the test scores obtained from the applied instruments (MoCA and BAS) as well as reaction times during the sentence completion task. These assessments are conducted preoperatively (T1) and at 3 days (T2), 3 months (T3), and 1 year (T4) after tumor resection. | — |
Countries
Germany
Contacts
Public ContactJohanna Scholtz
Universitätsklinik für Neurochirurgie, Evangelisches Klinikum Bethel
Outcome results
None listed