Interaction of cells in the periodontal ligament during orthodontic tooth movement

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039227

Enrollment

150

Registered

2026-02-05

Start date

2027-01-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K07.1 K07.2 K07.3 K07.4 K07.5

Interventions

Group 1: orthodontically treated incisors Group 2: incisors without orthodontic treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - Upper jaw: complete permanent dentition up to and including the first molars (part 1), permanent incisors (part 2) - Lower jaw: permanent incisors - Patients <22 years of age (part 1) or without upper age limit (part 2), provided that certain permanent teeth are present (see above). In accordance with physiological eruption times, this corresponds to a minimum age of 12 ± 1 years in Part 1 and 8 ± 1 years in Part 2. - Patients of any gender - Good oral health (approximal plaque index API = 40%) - No inflammatory processes such as gingivitis, periodontitis or abscesses (probing depth = 3 mm, no radiologically detectable bone loss) - Pre-therapeutic clinical diagnostics available (medical history, jaw models, OPG)

Exclusion criteria

Exclusion criteria: - Smoking - Use of non-steroidal anti-inflammatory drugs (NSAIDs) during the last month or antibiotics during the last 3 months prior to and during orthodontic treatment - Previous or current craniofacial fractures, craniofacial syndromes/anomalies, including cleft lip, jaw and palate - Untreated carious lesions - Autoimmune diseases

Design outcomes

Primary

Measure	Time frame
- cytokines in gingival crevicular fluid (CGF) - extent and velocity of orthodontic tooth movement of the upper incisors, determined by superimposition of digital dental casts - prevalence and extent of external root resorptions at the upper incisors, determined through a comparison of the pre-treatment orthopantomogram (OPG) and the OPG made after retraction of the upper incisors	—

Secondary

Measure	Time frame
- immune cells in the GCF - eventually expression of genes of immune cells in the GCF	—

Countries

Germany

Contacts

Public ContactEva Paddenberg-Schubert

Poliklinik für Kieferorthopädie, Universitätsklinikum Regensburg

eva.paddenberg@ukr.de+49 941 94416090

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026