Diffusion-weighted magnetic resonance imaging for the diagnosis of patients with lumbar nerve root entrapment syndromes

Diffusion-weighted magnetic resonance imaging for the diagnosis of patients with lumbar nerve root entrapment syndromes - DWI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039196

Enrollment

Registered

2026-02-03

Start date

2016-12-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M51.1

Interventions

Group 1: Group I: n=20 patients with acute, symptomatic lumbar disk herniation: Patients with acute (6 weeks) radicular (L1-S1) symptoms Clinical examination with DWI MRI of the lumbar spine before fu

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: -Adult patients/individuals (18yrs – 85yrs) -Patients (?18yrs) with a history of a) acute lumbosacral radicular symptoms (L4-S1 dermatome) caused by acute lumbar disk herniation and/or b) chronic spondylotic foraminal stenosis We will include patients with the clinical diagnosis of an acute (6 months) unilateral lumbar radicular symptoms. The diagnosis lumbar radiculopathy with be made by an Orthopaedic Surgeon according to the following criteria: radiation of leg pain distal to the knee, neurologic signs and symptoms including sensory symptoms, numbness, or pain in the L1-S1 dermatome, weakness in one or more adjacent myotomes (e.g. L4-S1: tibialis anterior- , extensor hallucis longus, peroneus longus/brevis muscle), or diminished deep tendon (patellar- and/or Achilles) reflex testing.

Exclusion criteria

Exclusion criteria: • Pediatric patients (<18yrs) • Severe active medical or psychiatric co-morbidities that would limit study participation • Previous back surgery

Design outcomes

Primary

Measure	Time frame
-To evaluate MRI DWI findings of the lumbar spinal nerves in symptomatic patients suffering from lumbar nerve root entrapment syndromes -To correlation pathomorphologic findings and with a) DWI images / ADC maps of symptomatic nerve roots with recently established normative values of asymptomatic, healthy individuals, b) and comparison of DWI images / ADC maps of symptomatic nerve roots with the unaffected contralateral side -To assess the diagnostic performance of MRI DWI technology in comparison to established diagnostic tools (standard MRI protocol, magnetic resonance myelography (MRM)	—

Measure

Time frame

-To evaluate MRI DWI findings of the lumbar spinal nerves in symptomatic patients suffering from lumbar nerve root entrapment syndromes -To correlation pathomorphologic findings and with a) DWI images / ADC maps of symptomatic nerve roots with recently established normative values of asymptomatic, healthy individuals, b) and comparison of DWI images / ADC maps of symptomatic nerve roots with the unaffected contralateral side -To assess the diagnostic performance of MRI DWI technology in comparison to established diagnostic tools (standard MRI protocol, magnetic resonance myelography (MRM)

—

Secondary

Measure	Time frame
-Subjective clinical findings / physical examination -Visual analogue scale (VAS) for back and leg pain -Oswestry disability index (ODI)	—

Countries

Germany

Contacts

Public ContactMaximilian Reinhold

Universitätsmedizin Göttingen

info@dr-reinhold.com+495513965101

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026