Follow-up on the impact of germ cell-damaging therapies on fertility – A retrospective data analysis of the years 2013 to 2023 based on a patient cohort from the FertiTOX study conducted by the Department of Women's Health in Tübingen

Follow-up on the impact of germ cell-damaging therapies on fertility – A retrospective data analysis of the years 2013 to 2023 based on a patient cohort from the FertiTOX study conducted by the Department of Women's Health in Tübingen - FertiTOX_FU

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039186

Enrollment

150

Registered

2026-01-30

Start date

2025-09-26

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fertility preservation counseling prior to gonadotoxic therapy

Interventions

Group 1: Patients who attended fertility preservation counseling prior to gonadotoxic therapy and agreed to participate in the FertiTOX study

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Presentation of patients in the Endocrinology and Reproductive Medicine Unit of the Department of Women's Health at the University Hospital of Tübingen (in the years 2013-2023) for consultation regarding fertility preservation

Exclusion criteria

Exclusion criteria: Missing relevant data

Design outcomes

Primary

Measure	Time frame
Change in ovarian reserve after gonadotoxic therapy, measured by anti-Müllerian hormone (AMH) levels in a comparison between baseline and follow-up	—

Secondary

Measure	Time frame
Change in FSH and estradiol between baseline and follow-up Proportion of patients with cycle abnormalities after therapy Use of fertility-preserving measures (type and frequency) Pregnancy rate during the follow-up period Occurrence of menopausal symptoms	—

Countries

Germany

Contacts

Public ContactMelanie Henes

Department für Frauengesundheit am Universitätsklinikum Tübingen

melanie.henes@med.uni-tuebingen.de+497071 82211

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026