Immediate effect of Plumpy'Nut intake on anabolic metabolism (measured by ketogenesis) with regard to the risk of refeeding syndrome
Conditions
Interventions
Group 1: The study aims to demonstrate the effects of the ready-to-use supplementary food 'Plumpy'Nut' on ketogenesis in healthy adults based on changes in beta-hydroxybutyrate concentration in the bl
Sponsors
Universitätsklinikum Münster, Klinik für Kinder- und Jugendmedizin, Allgemeine Pädiatrie, Bereich Angeborene Stoffwechselerkrankungen
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Ketogenic metabolic state after 3 days of food deprivation (verified by own beta-hydroxybutyrate measurements) - No metabolic diseases (diabetes mellitus, hyperinsulinemia) - No endocrine diseases (Cushing's syndrome, hyper-/hypothyroidism) - Non-smoker - No regular intake of medication - No intake of nutritional supplements at least 7 days before and during the intervention period - Pregnancy/breastfeeding - BMI < 30 - No mental illness, including eating disorders - No blood donation during the fasting period or two weeks before and after
Exclusion criteria
Exclusion criteria: -Pregnancy/breastfeeding -Diabetes mellitus/hyperinsulinemia metabolic disorders -Endocrine disorders (Cushing's syndrome, hyper-/hypothyroidism) -Peanut allergy, lactose intolerance -Drug addiction/alcohol abuse -Smokers -Mental illness, including eating disorders (bulimia, anorexia) -BMI > 30 -Regular intake of medication/nutritional supplements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The target criterion (?Diff) is defined as the difference between the maximum change of beta-hydroxybutyrate levels following Plumpy’Nut® intake (?ßOHBPlumpy’Nut®) and the beta-hydroxybutyrate fluctuations on day 3 (?ßOHBDay3). H0 ?Diff = ?ßOHBPlumpy’Nut® - ?ßOHBDay3 = 0 H1 ?Diff ? 0 | — |
Secondary
| Measure | Time frame |
|---|---|
| In Addition we monitored the blood glucose levels while fasting and hourly for 5 hours after the intervention. Insulin, vitamin B1, phosphate, potassium, sodium, calcium, chloride, cholesterol, HDL, LDL and triglycerides were measured in the blood before and hourly for 5 hours after the intervention | — |
Countries
Germany
Contacts
Public ContactThorsten Marquardt
Universitätsklinikum Münster, Klinik für Kinder- und Jugendmedizin, Allgemeine Pädiatrie, Bereich Angeborene Stoffwechselerkrankungen
Outcome results
None listed