Pilot study investigating the association between BK polyomavirus (BKPyV) and graft-versus-host disease (GvHD)

Pilot study investigating the association between BK polyomavirus (BKPyV) and graft-versus-host disease (GvHD) - Ass_BKPyV_GvHD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039127

Enrollment

Registered

2026-01-29

Start date

2026-01-25

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Z94

Interventions

Group 1: Retrospective evaluation of allogeneic stem cell transplant patients with BKPyV viremia and/or viruria and evidence of GvHD

no comparison group

the histological sections of GvHD in these patients are examined for BKPyV using PCR, immunohistochemistry, and RNA in situ hybridization.

Eligibility

Sex/Gender

All

Age

0 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Within the studies (ethics votes BB 116/13 or BB 146/15) BKPyV viruria or viremia - Histologically confirmed cutaneous GvHD and availability of paraffin blocks

Exclusion criteria

Exclusion criteria: None have been defined.

Design outcomes

Primary

Measure	Time frame
Description and virus detection in the available skin biopsies using immunohistochemistry (IHC), polymerase chain reaction (PCR), and RNA in situ hybridization (RNAscope-ISH)	—

Secondary

Measure	Time frame
None has been defined.	—

Countries

Germany

Contacts

Public ContactLaila Schneidewind

Universitätsmedizin Greifswald

laila.schneidewind@uni-greifswald.de+49 3834 8622025

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026