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Comparison of pre- versus post-incisional trocar-site infiltration with long-acting local anesthetics for reducing postoperative pain after laparoscopic cholecystectomy and laparoscopic inguinal hernia repair: a randomized controlled trial

Comparison of pre- versus post-incisional trocar-site infiltration with long-acting local anesthetics for reducing postoperative pain after laparoscopic cholecystectomy and laparoscopic inguinal hernia repair: a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00039116
Enrollment
200
Registered
2026-01-29
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain after laparoscopic cholecystectomy and laparoscopic inguinal hernia repair, with particular focus on pain at abdominal wall trocar insertion sites.

Interventions

Group 1: Study Arm 1 – Pre-incisional Infiltration (Pre-I group) Patients allocated to this study arm receive pre-incisional trocar-site infiltration. Before skin incision, ropivacaine 0.75% is infil

Sponsors

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age = 18 years Scheduled elective laparoscopic cholecystectomy or inguinal hernia repair Ability to understand the study procedures and provide written informed consent ASA physical status I–III Procedure performed using a standard Muli-port laparoscopic technique

Exclusion criteria

Exclusion criteria: Known allergy or hypersensitivity to amide-type local anesthetics (e.g., ropivacaine) Chronic pain syndromes or regular preoperative opioid use Acute cholecystitis or emergency surgery Conversion to open cholecystectomy Previous upper abdominal surgery with significant scarring Severe hepatic or renal impairment Pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
The primary endpoint is postoperative pain intensity, assessed using the visual analog scale (VAS). Specifically: VAS pain scores at rest and during coughing measured at predefined time points: immediately after awakening from anesthesia 1, 3, 6, 24, and 48 hours postoperatively.—

Secondary

MeasureTime frame
Secondary endpoints include: Total postoperative intravenous analgesic consumption within the first 48 hours Requirement for opioid analgesics (yes/no, cumulative dose) Occurrence of systemic adverse events related to opioid analgesics—

Countries

Germany

Contacts

Public ContactAhmed Alwali

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock

ahmed.alwali@med.uni-rostock.de+49381494146166

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026