F50
Conditions
Interventions
Group 1: Adolescent female patients with typical or atypical anorexia nervosa (AN) are examined at the time of acute malnutrition (AN-S). The assessment includes:
1. Resting electroencephalography (EE
Sponsors
Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Universitätsklinikum RWTH Aachen
Eligibility
Sex/Gender
Female
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: Age: 12;00 bis 17;11 years Patients (AN – Starvation): - Diagnosis of typical AN (F.50.00/F50.01) or atypical AN (F50.1; aAN) according to DSM-5/ICD-10 criteria (World Health Organization, 2016) and in inpatient or stepped-care treatment - %EBW: AN < 85%; aAN 85%–95% - low fT3 - Primary or secondary amenorrhea - ChEDE-Q score = 4 Patients (AN – WR): - Currently diagnosed with anorexia nervosa according to DSM-5/ICD-10 criteria (F50.1; World Health Organization, 2016), in inpatient or stepped-care treatment - %EBW: = 90% or individually determined minimum weight - normal fT3 Control group: - No psychiatric diagnosis - Normal body weight (%EBW = 85%) - Written informed consent from legal guardians and from the participant - Sufficient proficiency in German
Exclusion criteria
Exclusion criteria: - Current suicidality - Intellectual disability - Severe medical, neurological, or developmental disorders (including dermatological conditions of the scalp) - Implanted electrical or metallic medical devices incompatible with EEG/MRI - Patients with involuntary hospital treatment or restriction by legal or court order
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spectral power in the theta (4–7 Hz), alpha (8–12 Hz), and beta (13–30 Hz) frequency bands, as well as functional (coherence) and directional connectivity within the salience network (insula–ACC), the default mode network (mPFC–PCC), and the frontoparietal network (DLPFC–IPL) using resting-state electroencephalography (EEG) in a single-session measurement. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints will be used to investigate associations between EEG-based network parameters and clinical variables, including the severity of eating disorder symptoms, comorbid psychopathology, emotion regulation, endocrine markers, and weight parameters. In addition, structural, microstructural, and neurometabolic brain changes will be exploratively assessed to investigate potential relationships between functional network changes, brain structure, and clinical parameters. For patients with measurements at two time points, exploratory longitudinal analyses will be conducted to examine both individual neurofunctional changes between acute malnutrition and weight rehabilitation, as well as associations with changes in clinical parameters. Clinical interview and questionnaires: - Diagnostisches Interview bei psychischen Störungen im Kindes- und Jugendalter (K-DIPS; Schneider et al., 2017) - Child Eating Disorder Examination Questionnaire (ChEDE-Q; Hilbert, 2016) - Eating Disorder Inventory (EDI-2; Paul & Thiel, 2005) - Beck-Depressions-Inventar Revised (BDI-2; Hautzinger et al., 2006) - Spence Children’s Anxiety Scale (SCAS; Essau et al., 2002) - Emotion Regulation Questionnaire (ERQ; Abler & Kessler, 2009) - Pubertal Developmental Scale (PDS; Petersen et al., 1988) | — |
Countries
Germany
Contacts
Public ContactBrigitte Dahmen
Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Uniklinik RWTH Aachen
Outcome results
None listed