K02.9
Conditions
Interventions
Group 1: Volunteers will receive a splint containing enamel slabs. They will be asked to wear the splint for 24 hours. The splint is used to collect in situ bacteria biofilm. Different treatment optio
Sponsors
Dentaltek Research AG
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Signed informed consent form - No general medical condition which represents a contraindication to wear the study specific splint for 24 hours - Full or partial dentition where intraoral splint fixation is possible - Periodontally healthy (PPD = 3mm except third molars) - No active caries
Exclusion criteria
Exclusion criteria: - Inability to follow or comply with the study procedures - Smoking more than 10 cigarettes per day - Alcohol abuse, drug or medication addicts - Poor oral hygiene (plaque index > 20%) - Untreated periodontitis - Severe systemic disease - Diseases of the salivary glands or the oral mucosa - Uncontrolled diabetes (HbA1c >6) - Antibiotics or local antimicrobials or fluoridated mouth rinses within the last 30 days - Participation in another study - Pregnancy or lactating mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live/dead assay after application of photodynamic therapy (PDT) on a 24 hours human biofilm (ex-situ). | — |
Secondary
| Measure | Time frame |
|---|---|
| Cell viability test before and after treatment of the specimen Results of the repeated experiments (saliva) | — |
Countries
Switzerland
Contacts
Public ContactPune Paqué
Universität Zürich
Outcome results
None listed