Flexible versus rigid endoscopic therapy for Zenker’s diverticulum: a retrospective cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039092

Enrollment

130

Registered

2026-01-26

Start date

2023-02-01

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K22.5

Interventions

Group 1: flexible endoscopic myotomy (Endoscopy) Retrospective analysis of all patients with Zenker's diverticulum treated consecutively from January 2009 to October 2021 at a single tertiary center,

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All consecutive patients treated between January 1, 2009, and October 31, 2021.

Exclusion criteria

Exclusion criteria: Patients without written consent for endoscopic or surgical treatment

Design outcomes

Primary

Measure	Time frame
Clinical improvement (reduction or absence of symptoms) 3 months post-procedure, evaluated during a clinical visit	—

Secondary

Measure	Time frame
1. Major complications: (a) bleeding requiring surgery, endoscopic reintervention, or red blood cell transfusion; (b) perforation requiring surgery or endoscopic reintervention for placement of covered metal stents or initiation of vacuum-assisted closure (VAC) therapy; and (c) mediastinitis with clinical and radiological signs on computed tomography (CT), requiring surgery or escalation of antibiotic therapy and resulting in a prolongation of hospital stay of =4 nights. 2. Minor complications: (a) intraprocedural perforation with visible mediastinal opening, adequately closed with clips, without subsequent signs of mediastinitis under antibiotic therapy and with hospital stay prolonged by =3 nights; (b) emphysema without clinical or radiological signs of mediastinitis on CT, managed conservatively; (c) post-procedural fever with significant elevation of inflammatory parameters, without clinical or radiological signs of mediastinitis, requiring antibiotic therapy and with hospital stay prolonged by =3 nights. 3. Time to resumption of oral intake [days] 4. Procedure duration [minutes] 5. length of hospital stay [days] 6. recurrence rate of symptomatic Zenker´s diverticulum 7. Need for reintervention	—

Measure

Time frame

1. Major complications: (a) bleeding requiring surgery, endoscopic reintervention, or red blood cell transfusion; (b) perforation requiring surgery or endoscopic reintervention for placement of covered metal stents or initiation of vacuum-assisted closure (VAC) therapy; and (c) mediastinitis with clinical and radiological signs on computed tomography (CT), requiring surgery or escalation of antibiotic therapy and resulting in a prolongation of hospital stay of =4 nights. 2. Minor complications: (a) intraprocedural perforation with visible mediastinal opening, adequately closed with clips, without subsequent signs of mediastinitis under antibiotic therapy and with hospital stay prolonged by =3 nights; (b) emphysema without clinical or radiological signs of mediastinitis on CT, managed conservatively; (c) post-procedural fever with significant elevation of inflammatory parameters, without clinical or radiological signs of mediastinitis, requiring antibiotic therapy and with hospital stay prolonged by =3 nights. 3. Time to resumption of oral intake [days] 4. Procedure duration [minutes] 5. length of hospital stay [days] 6. recurrence rate of symptomatic Zenker´s diverticulum 7. Need for reintervention

—

Countries

Germany

Contacts

Public ContactChristian Meinhardt

Klinikum Oldenburg AöR, Universitätsklinik für Innere Medizin III - Gastroenterologie

gastroenterologie@klinikum-oldenburg.de+494414032581

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026