Healthy volunteers
Conditions
Interventions
Group 1: Participants in age-appropriate good health, without acute inflammatory pain or infections, provide single blood, urine, and stool samples. Health status is assessed through a structured inte
Sponsors
Universität Bielefeld
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: • Adult volunteers who, in the opinion of the PIs, are in good health for their age, including those with chronic conditions that are controlled by medication. Health status is assessed in a structured interview. • 18 years of age or older • Not pregnant • Body weight = 50 kg • BMI 18–28 kg/m² • At least 1 year of abstinence from nicotine products • At least 1 week of abstinence from vitamins and fish oil products • Presence of documented consent
Exclusion criteria
Exclusion criteria: • Known rheumatological disease • Chronic diseases that, in the opinion of the PIs, are not or insufficiently controlled by medication • Malignant tumors that have not been in permanent remission for the past 5 years • Severe or recurrent infection in the recent past • Test subjects who have received an experimental drug or are participants in a drug study • Subjects who have received an experimental drug or are participants in a drug study • Subjects who have used an invasive medical device within the last 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim of this project is to characterize inter-individual variability in inflammatory signaling pathways using biosamples and associated demographic and health data from donors in age-appropriate good health (“healthy” volunteers). | — |
Secondary
| Measure | Time frame |
|---|---|
| - COX-1 and COX-2 activity in vivo and ex vivo - Quantification of cyclooxygenase expression in blood immune cells - Characterization of the cyclooxygenase biosynthesis and signaling network in immune cells using OMICs technologies - Characterization of interactions between cyclooxygenase inhibitors and the gut microbiome ex vivo | — |
Countries
Germany
Outcome results
None listed