Influence of proton pump inhibitor (PPI) therapy on postoperative morbidity and mortality after major liver resection

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038981

Enrollment

550

Registered

2026-02-24

Start date

2026-02-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morbidity after major liver resection

Interventions

Group 1: Preoperative PPI-therapy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient age >18 years, retrospective evaluation of all patients who underwent major liver resection between January 1, 2006, and December 31, 2024.

Exclusion criteria

Exclusion criteria: Patient age < 18 years, combination of major liver resection with another oncological procedure, missing or insufficient information regarding pre- or postoperative PPI therapy based on retrospective data

Design outcomes

Primary

Measure	Time frame
The primary endpoint is morbidity after major liver resection in patients with and without PPI therapy. This is assessed using the Clavien-Dindo classification for postoperative complications in the period from surgery to discharge.	—

Secondary

Measure	Time frame
1. Biliary complications after major liver resection in patients with and without PPI therapy 2. Number of microorganisms per patient in collected bile duct swabs	—

Countries

Germany

Contacts

Public ContactLukas Pollmann

Klinik für Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena

Lukas.Pollmann@med.uni-jena.de+4915228948100

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026