In an experimental model, the influence of cognitive performance and physical activity on the development of chronic pain is being investigated.
Conditions
Interventions
Group 1: Arm 1: Experimental cognitive performance intervention (5 sessions of 45 minutes each on 5 consecutive days)
Group 2: Arm 2: Experimental physical performance intervention (5 sessions of 45 m
Sponsors
Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Healthy adult participants, male and female, who are fully capable of making decisions and able to understand the informed consent, and who are able to reliably perform the stimulus assessments. Body Mass Index: 18 to 30
Exclusion criteria
Exclusion criteria: - Acute or chronic pain (including muscle soreness) - Presence of acute or chronic somatic or psychiatric conditions (based on self-report or routine examination) - Presence of MRI-specific exclusion criteria (claustrophobia, pacemakers, non-MRI-compatible metallic implants) - Participation in studies involving medication or regular medication intake (except thyroid medication, allergy medication, occasional use of painkillers, or contraceptives) - Use of painkillers within the last 24 hours before the examination - Pregnancy or breastfeeding - Acute skin condition or injury at the stimulation sites - Acute respiratory illness or symptoms - No past or current physical opioid dependence - No cardiovascular diseases - No nervous system disorders - No immune system disorders - No gastrointestinal diseases - No use of cardiotoxic medications/substances (e.g., cocaine, methamphetamine, cyclic antidepressants, calcium channel blockers, beta-blockers, digoxin)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective pain ratings, using a visual analogue scale (VAS), determined before, during and after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative Sensibility Thresholds (QST), before and after the intervention. Functional brain activation and brain structure during multi-modal pain stimulation (heat and pressure) and rest in magnetic resonance imaging (MRI), before and after the intervention. | — |
Countries
Germany
Contacts
Public ContactChristian Büchel
Universitätsklinikum Hamburg-Eppendorf, Institut für Systemische Neurowissenschaften
Outcome results
None listed