I67.8
Conditions
Interventions
Group 1: Observational group including patients with cerebral small vessel disease without imaging evidence of an acute ischemic stroke. Participants are followed prospectively for 12 months. Study pr
Sponsors
Universitätsklinikum Ulm
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age = 18 years Evidence of cerebral small vessel disease on MRI (white matter hyperintensities Fazekas grade 1–3) Assignment to one of the three study groups: 1. no acute ischemic stroke 2. acute lacunar ischemic stroke 3. acute territorial ischemic stroke Ability to provide written informed consent Sufficient German language skills to participate in study procedures
Exclusion criteria
Exclusion criteria: Other plausible causes of white matter hyperintensities than cerebral small vessel disease (e.g. inflammatory CNS disorders, leukodystrophies, brain tumors) Known neurodegenerative diseases (e.g. Parkinson’s disease, dementia) Acute or recent traumatic brain injury Contraindications to MRI examination Pregnancy or breastfeeding Life expectancy < 1 year Inability to participate in the study or to comply with follow-up visits
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation of longitudinal changes in blood biomarkers with cerebral small vessel disease progression assessed by serial MRI over 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of biomarker trajectories between study groups. Association of biomarkers with additional MRI markers (WMH, microbleeds, lacunes, atrophy). Occurrence of cerebrovascular events during follow-up. | — |
Countries
Germany
Contacts
Public ContactMona Laible
Universitätsklinikum Ulm
Outcome results
None listed