Pain Processing
Conditions
Interventions
Group 1: Participants take part in the experimental paradigm. This consists of a pain calibration, a cognitive pain experiment in the MRI, during which we will induce pain expectations, and questionna
Sponsors
Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: • Healthy participants of full age, able to provide informed consent and capable to reliably rate pain • Body mass index: 18 - 30
Exclusion criteria
Exclusion criteria: - Acute or chronic illness - MR-specific exclusion criteria - Participation in drug studies - Regular drug use - Intake of painkillers within 24 hours of study procedures - Use of illegal substances - Pregnancy or breastfeeding - Acute skin disease or lesion on stimulation sites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the study is to investigate how the influence of expectation on pain perception decreases with increasing difference between pain and expectation. This will be measured with pain ratings on a visual analogue scale (VAS) and analysed using behavioural computational models. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary aim is to investigate the neural underpinnings of this gradual integration which will be measured in the MR with BOLD (Blood-oxygenation-level–dependent) signal. | — |
Countries
Germany
Contacts
Public ContactZoe Hilker
Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf
Outcome results
None listed