Multivariable Prediction of Hypotension during General Anesthesia using Preoperative Nocturnal Blood Pressure Data

Multivariable Prediction of Hypotension during General Anesthesia using Preoperative Nocturnal Blood Pressure Data - ENHANCED

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038914

Enrollment

450

Registered

2026-01-08

Start date

2025-03-14

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Hypotension I95.9

Interventions

Group 1: Preoperatively, non-invasive nocturnal blood pressure monitoring and transthoracic echocardiography are performed. Perioperatively, routinely collected vital parameters are monitored, with pa

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Elective, non-cardiac surgery under general anesthesia - Possession of health insurance - Provision of written informed consent - Presence of at least one cardiovascular risk factor (CVRF) and/or an established cardiovascular disease (CVD) in accordance with current guidelines

Exclusion criteria

Exclusion criteria: - Contraindications to 24-hour blood pressure monitoring - Intensive care unit admission within the last 30 days - Pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame
Performance of the hypotension prediction model measured as the area under the receiver operating characteristic curve (AUROC). Hypotension is defined as a mean arterial pressure (MAP) < 65 mmHg or the need for vasopressor therapy to maintain a MAP of at least 65 mmHg. Post-induction hypotension (PIH) is defined as hypotension occurring after induction of general anesthesia until surgical incision, with particular focus on the first 15 minutes after anesthesia induction. Intraoperative hypotension (IOH) is defined as hypotension occurring from surgical incision until the end of anesthesia. Data analysis is based on medical history, data from non-invasive nocturnal blood pressure monitoring, transthoracic echocardiography (TTE), and the hospital information system	—

Measure

Time frame

Performance of the hypotension prediction model measured as the area under the receiver operating characteristic curve (AUROC). Hypotension is defined as a mean arterial pressure (MAP) < 65 mmHg or the need for vasopressor therapy to maintain a MAP of at least 65 mmHg. Post-induction hypotension (PIH) is defined as hypotension occurring after induction of general anesthesia until surgical incision, with particular focus on the first 15 minutes after anesthesia induction. Intraoperative hypotension (IOH) is defined as hypotension occurring from surgical incision until the end of anesthesia. Data analysis is based on medical history, data from non-invasive nocturnal blood pressure monitoring, transthoracic echocardiography (TTE), and the hospital information system

—

Secondary

Measure	Time frame
- Incidence of PIH and IOH with MAP values 2 flights - Duke Activity Status Index (DASI) - Number of antihypertensive medications in long-term therapy	—

Countries

Germany

Contacts

Public ContactSascha Treskatsch

Charité, Klinik für Anästhesiologie und Intensivmedizin, Campus Benjamin Franklin

sascha.treskatsch@charite.de+4930450517222

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026