Effects of Inhalational Versus Intravenous Anesthesia on Intraoperative Oxygen Affinity

Effects of Inhalational Versus Intravenous Anesthesia on Intraoperative Oxygen Affinity - IN-O2-AFF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038902

Enrollment

104

Registered

2026-01-07

Start date

2024-01-16

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oxygen Affinity

Interventions

Group 1: Patients undergoing general anesthesia with sevoflurane as the primary anesthetic agent. Group 2: Patients undergoing general anasthesia with propofol as the primary anesthetic agent.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All adult patients who are capable of providing informed consent, who are scheduled for elective surgery under general anesthesia with either sevoflurane or propofol, and who have an ASA physical status classification of I–III may be included.

Exclusion criteria

Exclusion criteria: Patients undergoing non-elective surgery, patients lacking capacity to give informed consent, pregnancy

Design outcomes

Primary

Measure	Time frame
Changes of oxygen dissociation curve (p50), pre, intra, during and postoperative measured via venous blood gas analysis	—

Secondary

Measure	Time frame
Changes of volume adjusted fractional oxygen extraction	—

Countries

Germany

Contacts

Public ContactOliver Opatz

Charité, KLinik für Anästhesiologie und Intensivmedizin, Campus Benjamin Franklin

oliver.opatz@charite.de+4930450517222

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026