Nutrient deficiency in preterm infants
Conditions
Interventions
Group 1: 20 preterm infants (28 0/7- 31 6/7 weeks at birth) with choline-supplementation. Infants receive supplemental choline (30mg/kg/d as glycerophosphocholine) when oral feedings >100ml/kg/d are e
Sponsors
Universitätsklinik für Kinder- und Jugendmedizin Tübingen, Neonatologie
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Group 1 - Preterm infants 28 0/7 - 31 6/7 gestational weeks - Group 2 - Term-born infants >37 0/7 gestational weeks - In case of multiple births: Only firstborn infant can be included, intervention in siblings possible if desired by the parents
Exclusion criteria
Exclusion criteria: • Malformations • Syndromal diseases • Metabolic diseases • SGA-growth (5mg/dl during the 1st week after birth • Circulatory support (hydrocortisone or catecholamine therapy) in the first week after birth • Gestational diabetes (with hypertrophy (>P90) or recurrent hypoglycaemia in the first days of life) • Gastrointestinal complications (e.g. intestinal perforation) or incomplete transition to full enteral feeding until/at day 14 after birth • Mother not willing to participate as associate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of methylation of DNA at PMA 36-38 weeks after preterm delivery with and without choline supplementation (methyl-group-donor) compared to healthy term born infants as 0-100% methylated Guanosin-Bases | — |
Secondary
| Measure | Time frame |
|---|---|
| - Choline plasma concentration at PMA 36-38 weeks - Betaine and PC plasma concentrations at PMA 36-38 weeks - Fat mass and proportion of fat mass of total body mass at PMA 36-38 weeks | — |
Countries
Germany
Contacts
Public ContactAxel R. Franz
Universitätsklinikum für Kinder- und Jugendmedizin Tübingen, Neonatologie
Outcome results
None listed