M62.50
Conditions
Interventions
Group 1: Two Geriatric patients with IGF-I-deficiency (one patient with GH-resistance, one patient withour GH-resistance) associated (pre)sarcopenia ingest 30g of dietary protein within 5 minutes an
Sponsors
LMU Klinikum München, Medizinische Klinik und Poliklinik IV, AG Sarkopenie
Eligibility
Sex/Gender
Female
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: existing (pre-)sarcopenia and IGF-I deficiency signed declaration of consent
Exclusion criteria
Exclusion criteria: Insufficient capacity to give consent Legal guardianship Diagnosed muscle disease (myasthenia gravis, muscular dystrophy, amyotrophic lateral sclerosis (ALS), poliomyelitis) Uncontrolled diabetes mellitus Tumour disease within the last 5 years Allergy to milk protein or lactose intolerance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolite concentrations in venous blood plasma measured by targeted liquid chromatography mass spectrometry at baseline and 45 and 120 minutes after consumption of a protein-rich drink | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of total ghrelin, IGF-I, GH, insulin, glucose and triglycerides in venous blood plasma or serum at baseline, as well as 45 and 120 minutes after consuming a protein-rich liquid meal, and changes in appetite using a visual analogue scale. Group differences in risk of malnutrition (using Mini Nutritional Assessment), body composition (using DXA), results of geriatric assessments. | — |
Countries
Germany
Contacts
Public ContactLinda Deißler
LMU Klinikum München, Medizinische Klinik und Poliklinik IV, AG Sarkopenie
Outcome results
None listed