Age-related changes in motor and cognitive performance in older adults (including individuals with Mild Cognitive Impairment/MCI detected during screening).
Conditions
Interventions
Group 1: Intervention Group: Multimodal, progressive training program designed to simultaneously promote motor and cognitive skills (Dual-Task).
- Duration: 12 weeks.
- Frequency: 2 sessions per week
Sponsors
TU Chemnitz
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: - A medical certificate confirming fitness for light to moderate physical activity. - Subjects must be able to walk without walking aids. - Native-level German language skills. - Ability to attend the examinations independently or accompanied by a trusted person.
Exclusion criteria
Exclusion criteria: - Lack of capacity to consent. - Diagnosed and medically treated mental illnesses (e.g., major depression) or neurocognitive disorders (e.g., confirmed dementia). - History of neurological diseases (e.g., epilepsy, Parkinson's disease) or traumatic brain injury. - Severe impairments of the cardiovascular (e.g., decompensated heart failure, severe cardiac arrhythmias), pulmonary (e.g., severe cor pulmonale, uncontrolled bronchial asthma), or musculoskeletal systems (e.g., immobility, acute pain syndrome, orthopedic surgeries in the last 6 months) that make participation in the examinations impossible. - Diabetic neuropathy (e.g., diabetic foot syndrome). - Harmful substance use or dependence (including alcohol). - Language comprehension disorders. - Current participation in another clinical study (e.g., testing new anti-dementia drugs).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome : Postural Control (Balance Ability) and Brain Activity. Time Frame: T0 (Baseline), T1 (after 12 weeks of intervention), T2 (Follow-up) Description: Measurement of Center of Pressure (CoP) sway using a force plate (Gk-1000 Koordinator) in parallel and semi-tandem stance under single- and dual-task conditions. Simultaneous measurement of cortical activity is performed using functional near-infrared spectroscopy (fNIRS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional & Cognitive Tests Outcome: Cognitive Screening Measurement Method: MoCA Test (Montreal Cognitive Assessment). Time Frame: T0 (Baseline), T1 (Post-Intervention), T2 (Follow-up). Outcome : Functional Mobility and Gait Parameters Measurement Method: Timed Up and Go (TUG) Test (Single & Dual Task) including gait analysis via pressure plate (Zebris FDM 1.5) and 5x Sit-to-Stand Test. Time Frame: T0, T1, T2. Outcome : Executive Functions and Attention Measurement Method: Flanker Arrow Test, Digit Span (Forward/Backward), Trail Making Test (Part A & B). Time Frame: T0, T1, T2. Outcome: Dual-Task Interference and Processing Speed Measurement Method: Auditory Stroop Test (Colors/Voice Gender) and Animal Naming (Verbal Fluency). Time Frame: T0, T1, T2. Subjective Questionnaires (Patient-Reported Outcomes) Outcome : Fear of Falling and Fall History Measurement Method: Falls Efficacy Scale (FES) and Falls History Questionnaire. Time Frame: T0, T1, T2. Outcome : Physical Activity Level Measurement Method: German Physical Activity Questionnaire 50+ (German-PAQ-50+). Time Frame: T0, T1, T2. Outcome : Subjective Cognitive Performance Measurement Method: FLei-Test (Questionnaire regarding mild cognitive limitations / "Fragebogens zur subjektiven Einschätzung der geistigen Leistungsfähigkeit"). Time Frame: T0, T1, T2. Outcome : Social Situation Measurement Method: Social Questionnaire according to Nikolaus ("Sozialfragebogen nach Nikolaus"). Time Frame: T0, T1, T2. | — |
Countries
Germany
Contacts
Public ContactJesus Alejandro Escalona Navarro
TU Chemnitz
Outcome results
None listed