neurotrophe keratopathy
Conditions
Interventions
Group 1: Examination of the subbasal nerve plexus using corneal confocal microscopy in various eye diseases associated with neurotrophic keratopathy and correlation with different clinical parameters.
Sponsors
Charité
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Individuals over 18 years of age with a clinical suspicion of, or otherwise confirmed diagnosis of, - Fuchs endothelial dystrophy - bullous keratopathy - keratoconus - ocular graft-versus-host disease - iris or choroidal melanoma - conjunctival neoplasia - corneal vascularization - keratitis The prerequisite is that the patients are capable of giving informed consent and agree to the procedure.
Exclusion criteria
Exclusion criteria: Age <18 years Missing consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In eye diseases associated with neurotrophic keratopathy, there is a rarefaction of the subbasal nerve plexus, as shown by corneal confocal microscopy. • CNFL (corneal nerve fiber length): length of all nerve fibers + branches mm/mm2 before and 3 and 12 months after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| • CNFD (corneal nerve fiber density): total number of major nerve fibers no/mm2 • CNBD (corneal nerve branch density): number of branches no/mm2 • DCF Dendritic cell with nerve fiber contact • DCP Dendritic cell without nerve fiber contact • NCF Non-dendritic cells with nerve fiber contact • NCP Non-dendritic cells without nerve fiber contact | — |
Countries
Germany
Contacts
Public ContactAnna-Karina Maier-Wenzel
Charité
Outcome results
None listed