Postoperative determination of calprotectin in drains as an early biomarker for infections or anastomotic insufficiency after rectal resection

Postoperative determination of calprotectin in drains as an early biomarker for infections or anastomotic insufficiency after rectal resection - PCDfB

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038769

Enrollment

Registered

2026-01-26

Start date

2026-04-30

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C20 D12.8

Interventions

Group 1: Elective rectal resection for carcinoma or a benign disease

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age = 18 years, planned elective rectal resection, placement of a postoperative drain near the anastomosis or surgical site (standardized procedure), written informed consent

Exclusion criteria

Exclusion criteria: Emergency surgeries, pre-existing chronic inflammatory bowel disease (e.g. Crohn's disease, ulcerative colitis), systemic, chronic inflammatory or autoimmune diseases (e.g. rheumatoid arthritis, active infectious diseases)

Design outcomes

Primary

Measure	Time frame
Course of calprotectin levels in serum and drainage fluid (on days 1, 3 and 5 postoperatively) in patients after rectal resection.	—

Secondary

Measure	Time frame
Primary study objective: Monitoring the course of calprotectin levels in serum and drainage fluid (preoperatively, on days 1, 3, and 5 postoperatively) in patients after rectal resection. Secondary study objectives: Comparison of the dynamics of calprotectin with conventional inflammatory markers (CRP, PCT, leukocytes) in the blood. Investigation of drainage fluid parameters (cell count, pH, lactate) and their relationship to calprotectin. Does the type of resection (e.g., with/without neoplasia) or surgical approach (open vs. minimally invasive) influence calprotectin levels? Tertiary study objective: Should complications (such as anastomotic leakage) occur, can a trend in calprotectin (increase in laboratory parameters) be demonstrated?	—

Measure

Time frame

Primary study objective: Monitoring the course of calprotectin levels in serum and drainage fluid (preoperatively, on days 1, 3, and 5 postoperatively) in patients after rectal resection. Secondary study objectives: Comparison of the dynamics of calprotectin with conventional inflammatory markers (CRP, PCT, leukocytes) in the blood. Investigation of drainage fluid parameters (cell count, pH, lactate) and their relationship to calprotectin. Does the type of resection (e.g., with/without neoplasia) or surgical approach (open vs. minimally invasive) influence calprotectin levels? Tertiary study objective: Should complications (such as anastomotic leakage) occur, can a trend in calprotectin (increase in laboratory parameters) be demonstrated?

—

Countries

Germany

Contacts

Public ContactThomas von Ahnen

Krankenhaus Agatharied

thomas.ahnenvon@khagatharied.de+49 8026 393 2444

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026