Influence of FMR1/FMRP-Expression on follicular maturation and ovarian reserve

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038754

Enrollment

2000

Registered

2026-01-05

Start date

2013-12-18

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ovarian reserve

Interventions

Group 1: POR (Poor Responder) POI (Premature Ovarian Failure/ Insufficiency) NOR (Normal Ovarian Response)/ Controls

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Clinical criteria: NOR • Patients from the IVF/ICSI program, without evidence of oocyte maturation disorders • AMH > 1.1 ng/ml • FSH 5-7 OR POR • DOR: Reduced ovarian reserve • AMH level 0.5 - 1.1 ng/ml • FSH level > 12 mIU/ml • Sonographic AFC (Antral Follicle Count) 40 mIU/ml • Sonographic AFC (Antral Follicle Count) usually equal to 0

Exclusion criteria

Exclusion criteria: Patients of the fertility clinic and hormone clinic of our department who, after medical history and explanation about this study, do not meet the above criteria

Design outcomes

Primary

Measure	Time frame
Evaluation of genetic differences Regular evaluations and publication of results Medical history questionnaire, clinical data, and experimental results	—

Secondary

Measure	Time frame
clinical data	—

Countries

Germany

Contacts

Public ContactJulia Rehnitz

Universitätsfrauenklinik- Abt. für Gynäkologische Endokrinologie und Fertilitätsstörungen

julia.rehnitz@med.uni-heidelberg.de+49 62215637346

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026