Risk Factors for Increased Blood Loss and Requirement of Blood Products and Vasopressor Support during Craniosynostosis Surgery in Children

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038719

Enrollment

Registered

2026-07-20

Start date

2025-02-24

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q75.0

Interventions

Group 1: Retrospective analysis of all children aged 0–1 year who underwent surgical treatment of craniosynostosis at Klinikum Großhadern between 2014 and 2024. Only existing routine data on periopera

Eligibility

Sex/Gender

All

Age

No minimum to 1 Years

Inclusion criteria

Inclusion criteria: Surgical treatment of craniosynostosis at Klinikum Großhadern (LMU Munich) between 01/01/2014 and 31/12/2024. Both sexes as well as syndromic and non-syndromic forms are included.

Exclusion criteria

Exclusion criteria: No explicit exclusion criteria were defined.

Design outcomes

Primary

Measure	Time frame
WHAT: Pre- and intraoperative risk factors (e.g. age, body weight, type of craniosynostosis, syndromic forms, surgical technique, baseline haemoglobin/haematocrit) and their association with increased perioperative blood loss and an increased requirement of blood products and circulatory-stabilizing medication. WHEN: Perioperative course until discharge. HOW: Retrospective collection of existing routine data from the anaesthesia record, surgical report, laboratory findings and patient chart.	—

Measure

Time frame

WHAT: Pre- and intraoperative risk factors (e.g. age, body weight, type of craniosynostosis, syndromic forms, surgical technique, baseline haemoglobin/haematocrit) and their association with increased perioperative blood loss and an increased requirement of blood products and circulatory-stabilizing medication. WHEN: Perioperative course until discharge. HOW: Retrospective collection of existing routine data from the anaesthesia record, surgical report, laboratory findings and patient chart.

—

Secondary

Measure	Time frame
WHAT: Perioperative blood loss (in ml and ml/kg body weight, calculated from administered/transfused volume and urine output as well as the haemoglobin/haematocrit course), type and amount of blood products administered, substance/dose/duration of circulatory-stabilizing or vasoactive medication, and perioperative body temperature. WHEN: Perioperative course until discharge. HOW: Retrospective collection of existing routine data from the anaesthesia record, surgical report, laboratory findings and patient chart.	—

Measure

Time frame

WHAT: Perioperative blood loss (in ml and ml/kg body weight, calculated from administered/transfused volume and urine output as well as the haemoglobin/haematocrit course), type and amount of blood products administered, substance/dose/duration of circulatory-stabilizing or vasoactive medication, and perioperative body temperature. WHEN: Perioperative course until discharge. HOW: Retrospective collection of existing routine data from the anaesthesia record, surgical report, laboratory findings and patient chart.

—

Countries

Germany

Contacts

Public ContactNikolaus Alexander Haas

Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Munich, Germany

Nikolaus.Haas@med.uni-muenchen.de+49 89 4400 73941

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026