microplastic exposure and possible associations with neurovascular dieseases
Conditions
Interventions
Group 1: Patients with neurovascular diseases
Study procedure: Single venous blood draw (approx. 5 ml) for microplastic particle analysis. No additional study-related interventions.
Group 2: Healthy v
Sponsors
Universitätsklinikum Heidelberg, Abteilung für Neuroradiologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Written informed consent - For patients: Presence of a neurovascular disease (e.g., ischemic stroke or intracranial aneurysm) - For healthy volunteers: No known cardiovascular, metabolic, or chronic inflammatory diseases
Exclusion criteria
Exclusion criteria: - Lack of informed consent - Pregnancy or breastfeeding - Acute or chronic infections - Known relevant cardiovascular, metabolic, or inflammatory diseases (for healthy volunteers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The concentration of microplastic particles in peripheral blood (particle count per mL), including size distribution and polymer composition. For the primary endpoint, a single blood sample is collected from each participant. Analysis is performed in an external specialized laboratory using validated micro-Fourier transform infrared spectroscopy (micro-FTIR). The blood sample is pseudonymized immediately after collection and transferred to the laboratory for processing. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraindividual variability of microplastic concentrations based on repeated blood sampling on different days. Influence of physiological states (fasting vs. postprandial). Comparison between subgroups of neurovascular diseases (e.g., acute events vs. elective patients). | — |
Countries
Germany
Contacts
Public ContactSophia Hohenstatt
Universitätsklinikum Heidelberg, Abteilung für Neuroradiologie
Outcome results
None listed