D66
Conditions
Interventions
Group 1: Patients with severe or moderate hemophilia and a 10-day intensive physiotherapy:
examination of joint health before, 1 and 2 weeks post start of physiotherapy and 3 months after intervention
Sponsors
Hämophiliezentrum/Hämostaseologie, Universitätsklinikum, Goethe Universität Frankfurt
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: • Severe or moderate hemophilia A or B (factor VIII/factor IX < 5%) • at least one target joint (knee, ankle, elbow) • continuous factor substitution or Emicizumab therapy
Exclusion criteria
Exclusion criteria: • Acute joint bleeding in last 4 weeks • planned surgical procedures in observation period • severe co-morbidities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint status/-functionality at 4 timepoints (before, 1 and 2 weeks post physiotherapy start and 3 months post intensive physiotherapy treatment): -physical examination (Hemophilia Joint Health Score) -Motility test (nach Tinetti) -Hemo-FAST questionnaire (ärztlicher Teil) -joint sonography (HEAD-US Score) | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient questionnaires at 4 timepoints (before, 1 and 2 weeks post physiotherapy start and 3 months post intensive physiotherapy treatment): - every day activites (Hemophilia Activity List, ACTIVLIM-Hemo, Hemo-FAST (patient part) - pain (Numeric rating scale) - health-related quality of life (ED-5Q) Furthers data collected from patient records: sex, age Type of Von Willebrand Disease and severity Von Willebrand and Factor VIII laboratory parameters Bleeding anamnesis (Annual bleeding rate, bleeding pattern, target joints) Therapy scheme Joint conditions (replacement/surgical interventions) Co-morbidities | — |
Countries
Germany
Contacts
Public ContactWolfgang Miesbach
Hämophiliezentrum/Hämostaseologie, Universitätsklinikum, Goethe Universität Frankfurt
Outcome results
None listed