Social modulation of chronic pelvic pain: Neural inter-individual co-variation and partner interaction

Social modulation of chronic pelvic pain: Neural inter-individual co-variation and partner interaction - ENDO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038689

Enrollment

150

Registered

2025-12-11

Start date

2026-02-16

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

endometriosis N80

Interventions

Group 1: Hyperscanning fMRI in 75 couples We will conduct hyperscanning fMRI in 75 romantic couples, including 25 healthy control couples and 50 couples in which the female partner has endometriosis.

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: • Age 18 – 45 years • Subjects with the ability to follow study instructions and likely to attend and complete all required visits • Written informed consent of the participant • Willingness of the participant to receive SMS to their own smartphones and fill out short questionnaires using the provided link • Being committed to an ongoing romantic relationship and living as a couple for at least 6 months • Subjects are able to speak, write and understand the German language sufficiently well (at the investigators discretion) to complete all required study procedures Additional inclusion criteria for patients: • Impairment due to chronic pelvic pain due to endometriosis

Exclusion criteria

Exclusion criteria: For all participants: • Withdrawal of participant consent (defined as a study participant who explicitly takes back his or her consent) • Standard MRI exclusion criteria (e.g., pregnancy, claustrophobia, pacemaker, artificial heart valves, cochlear implants, vessel clips, metal implants, prior brain surgery, permanent make-up, large scale tattoos on head or nape of the neck) • Current alcohol or drug dependence (F10.2-F19.2) Additional exclusion criteria for healthy controls: • Presence of a psychiatric disorder according to DSM-5, confirmed by Mini-International Neuropsychiatric Interview (Mini-DIPS) at V1. • Self-reported family history of any psychiatric disorder.

Design outcomes

Primary

Measure	Time frame
alterations of dyadic connectivity during real-time social interaction using fMRI hyperscanning in couples where women have endometriosis	—

Secondary

Measure	Time frame
relation between alterations of dyadic connectivity fMRI hyperscanning and data collected with questionnaires	—

Countries

Germany

Contacts

Public ContactLisa Raoul

central institute of mental health

lisa.raoul@zi-mannheim.de+4962117036806

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026