Determinants for the use of IL-1-Inhibitors in the treatment of Familial Mediterranean Fever

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038673

Enrollment

450

Registered

2026-01-12

Start date

2026-01-12

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E85.0

Interventions

Group 1: Retrospective analysis of all patients in whom Familial Mediterranean Fever was diagnosed and treated with IL-1-blocking therapy between 2004 and 2025.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Diagnosis of Familial Mediterranean Fever according to the Tel Hashomer criteria 3, Treatment in the Department of Rheumatology at the University Hospital Heidelberg (UKHD) between 01.01.2004, and 31.12.2025 3. Treatment with IL-1-inhibitors

Exclusion criteria

Exclusion criteria: 1. Patients who have not yet reached the age of 18 2. Incomplete patient records that preclude the analysis of indicators for IL-1 inhibitor therapy 3. Patients treated outside the UKHD or without documented treatment in the Department of Rheumatology 4. Patients without a documented follow-up visit

Design outcomes

Primary

Measure	Time frame
The aim of this study is to identify predictors for the use of continuous versus intermittent IL-1 inhibitor therapy in patients with FMF. The parameters to be analyzed (clinical and laboratory data) were collected during routine medical visits in the past. In addition, the PRAS score and ISSF score were recorded. Data retrieval is performed via the electronic medical records of the University Hospital Heidelberg (UKHD).	—

Measure

Time frame

The aim of this study is to identify predictors for the use of continuous versus intermittent IL-1 inhibitor therapy in patients with FMF. The parameters to be analyzed (clinical and laboratory data) were collected during routine medical visits in the past. In addition, the PRAS score and ISSF score were recorded. Data retrieval is performed via the electronic medical records of the University Hospital Heidelberg (UKHD).

—

Countries

Germany

Contacts

Public ContactNorbert Blank

Universitätsklinikum Heidelberg

Norbert.Blank@med.uni-heidelberg.de06221 2056-8030

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026