Healthy subjects under the age of 30 and over the age of 60 who are in good health, in particular those with no previous immunological or rheumatic diseases or operations in the treatment region, will be examined.
Conditions
Interventions
Group 1: 23 subjects under the age of 30 and 23 subjects aged 60 and over undergo blood sampling for testing for IL-1, TNF-alpha, IL-10 and determination of heart rate variability, osteopathic examina
Sponsors
HS Fresenius
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Younger adults between 18 and under 30 years of age (group 1). Older adults over 59 and under 80 years of age (group 2).
Exclusion criteria
Exclusion criteria: Exclusion criteria are chronic inflammation, rheumatic diseases, malignant diseases in the medical history, previous surgery (head and neck surgery, kidney and adrenal gland surgery, brain and spinal cord surgery, any surgery that causes vegetative symptoms, such as major abdominal or thoracic surgery), no free direction during examination (osteopathic red flag), and medication with immunosuppressants (including corticosteroids, tocilizumab, sarilumab, anti-TNF, JAK inhibitors, methotrexate, leflunomide, hydroxychloroquine, chloroquine) and a history of vasovagal syncope. Audible cardiac arrhythmias such as atrial fibrillation, atrial flutter, arrhythmias.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of inflammatory activity by determining IL-1, TNF-alpha, IL-10 in different age groups and HRV after specific vagus nerve treatment. The parameters are determined at 6 measurement points before and after treatment. Before the first and after the last measurement point, the DSF (German Pain Questionnaire) is administered as a validated questionnaire. The inflammation parameters are determined by blood sampling before and after treatment at each measurement point, as is heart rate variability. | — |
Countries
Germany
Contacts
Public ContactArmin Geilgens
HS Fresenius
Outcome results
None listed