Prevalence of malnutrition in progress of hematological-oncological diseases

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038583

Enrollment

100

Registered

2025-12-30

Start date

2016-06-14

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E64.0

Interventions

Group 1: Prospective, repeated monitoring of the incidence and progress of malnutrition in hematological-oncological patients with indication for allogeneic stem cell transplantation between 2016 and

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: - diagnosis of hematological-oncological disease (AML, ALL, MDS) or relapse of these diseases after previous complete remission, from the date of indication for allogeneic stem cell transplantation - Consent to participate to the study

Exclusion criteria

Exclusion criteria: - other debilitating illness - inability to understand the study protocol (psychiatric conditions such as: chronic schizophrenia, dementia, depression, or language barriers or cognitive impairments)

Design outcomes

Primary

Measure	Time frame
Primary endpoint: Assessment of the prevalence of malnutrition at different time points. Visits are conducted at four-week intervals before the planned allogeneic stem cell transplantation (HSCT), immediately before HSCT, and after day 30, 60, 90, 180, 270 and 365 days post-HSCT. Various parameters were recorded, including anthropometric parameters such as weight, height, body mass index (BMI), and waist and hip circumference. Handgrip strength was measured using a hand dynamometer, and body composition was assessed using bioimpedance analysis. Various questionnaires to assess malnutrition (Nutritional Risk Screening (NRS), Scored Patient-Generated Subjective Global Assessment (PG-SGA), and the Karnofsky Performance Index) were used. Quality of life was assessed using the EORTC QLQ-C30 questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC). In addition, various laboratory parameters that may indicate malnutrition were recorded (e.g. albumin, total protein).	—

Measure

Time frame

Primary endpoint: Assessment of the prevalence of malnutrition at different time points. Visits are conducted at four-week intervals before the planned allogeneic stem cell transplantation (HSCT), immediately before HSCT, and after day 30, 60, 90, 180, 270 and 365 days post-HSCT. Various parameters were recorded, including anthropometric parameters such as weight, height, body mass index (BMI), and waist and hip circumference. Handgrip strength was measured using a hand dynamometer, and body composition was assessed using bioimpedance analysis. Various questionnaires to assess malnutrition (Nutritional Risk Screening (NRS), Scored Patient-Generated Subjective Global Assessment (PG-SGA), and the Karnofsky Performance Index) were used. Quality of life was assessed using the EORTC QLQ-C30 questionnaire from the European Organisation for Research and Treatment of Cancer (EORTC). In addition, various laboratory parameters that may indicate malnutrition were recorded (e.g. albumin, total protein).

—

Secondary

Measure	Time frame
Correlation of malnutrition with various outcome parameters, such as primary diagnosis, genetic risk of the disease, response to therapy, length of hospital stay, and mortality.	—

Countries

Germany

Contacts

Public ContactKira Treiber

Universitätsklinikum Heidelberg

Team-Ernaehrungsmedizin.MED1@med.uni-heidelberg.de+49 6221 56 32449

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026