Patients with odontogenic infection and a history of penicillin allergy
Conditions
Interventions
Group 1: Prospective implementation of a risk-adapted PEN-FAST-based therapy and delabeling workflow for inpatients undergoing maxillofacial surgery with a documented history of penicillin allergy.
If
only evaluation of clinical courses and outcomes (length of stay, revisions, complications, therapy changes).
Sponsors
Bundeswehrzentralkrankenhaus Koblenz
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Capable of giving consent, documented history of penicillin allergy (without proven/confirmed allergy), inpatient admission for surgical treatment of odontogenic infections
Exclusion criteria
Exclusion criteria: Unable to give consent, pregnancy or breastfeeding, severe immunosuppression, patients with confirmed penicillin allergy (e.g. diagnosed by an allergist)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with documented penicillin allergy in whom the PEN-FAST-based treatment algorithm prevented clindamycin being prescribed during their hospital stay. | — |
Secondary
| Measure | Time frame |
|---|---|
| Process-related endpoints: • Proportion of patients who underwent oral provocation testing • Proportion with successful delabelling Outcome-related endpoints: • Length of hospital stay • CRP and leukocyte differential (48 hours after initiation of therapy) • Number of surgical revisions • Readmission rate within 30 days • Treatment failure rate (progression, necessary change of antibiotic therapy) • Occurrence of treatment-related complications (sepsis; spread of infection, e.g. mediastinal, cerebral; tracheotomy; intensive care required; death) | — |
Countries
Germany
Contacts
Public ContactAndrea Schmid
Bundeswehrzentralkrankenhaus Koblenz
Outcome results
None listed