Characterization of the immune response after surgical intervention – a pilot study

Characterization of the immune response after surgical intervention – a pilot study - PeriOp

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038565

Enrollment

150

Registered

2025-12-08

Start date

2025-12-08

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation in the perioperative setting

Interventions

Group 1: Changes in surface markers of neutrophils (including CD11b, CD62L, CXCR2, CD101, CD10) and monocytes (including CD14, CD16) Time points: 0 h (before skin incision), 2 h, 4 h, 6 h, 12 h, 24 h

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: elektive surgery 18 years or older

Exclusion criteria

Exclusion criteria: Under age no consent

Design outcomes

Primary

Measure	Time frame
Changes in surface markers of neutrophils (including CD11b, CD62L, CXCR2, CD101, CD10) and monocytes (including CD14, CD16) Time points: 0 h (before skin incision), 2 h, 4 h, 6 h, 12 h, 24 h (after skin incision) Clinical data collection Information such as medical history, vital parameters, laboratory findings, perioperative events, and postoperative complications is obtained from electronic medical records. Questionnaires and patient-reported outcomes Standardized and validated questionnaires are used to assess aspects such as pain. Biological samples Blood samples are collected at predefined time points before and after surgery. These samples are used for immunophenotyping via flow cytometry. Observation and clinical assessment Trained clinical staff or study personnel perform standardized assessments (e.g., vital signs at the time of blood collection). Electronic data capture All collected information is entered into a secure, password-protected electronic database and processed according to standardized protocols and quality control procedures.	—

Measure

Time frame

Changes in surface markers of neutrophils (including CD11b, CD62L, CXCR2, CD101, CD10) and monocytes (including CD14, CD16) Time points: 0 h (before skin incision), 2 h, 4 h, 6 h, 12 h, 24 h (after skin incision) Clinical data collection Information such as medical history, vital parameters, laboratory findings, perioperative events, and postoperative complications is obtained from electronic medical records. Questionnaires and patient-reported outcomes Standardized and validated questionnaires are used to assess aspects such as pain. Biological samples Blood samples are collected at predefined time points before and after surgery. These samples are used for immunophenotyping via flow cytometry. Observation and clinical assessment Trained clinical staff or study personnel perform standardized assessments (e.g., vital signs at the time of blood collection). Electronic data capture All collected information is entered into a secure, password-protected electronic database and processed according to standardized protocols and quality control procedures.

—

Secondary

Measure	Time frame
Vital parameters (heart rate, blood pressure, oxygen saturation) and pain (according to the NRS scale), as well as changes in venous blood gas analysis. Clinical course parameters (duration and invasiveness of the surgical procedure, length of hospital stay, need for intensive care, intra- and postoperative opioid requirements, postoperative wound-healing complications).	—

Countries

Germany

Contacts

Public ContactNana-Maria Wagner

Universtätsklinikum Würzburg, Klinik und Poliklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie

wagner_N2@ukw.de0931 2010 30105

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026