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Alveolar Ridge Preservation using Platelet Rich Fibrin (PRF) for prevention of gingival invaginations following orthodontic extraction space closure

Alveolar Ridge Preservation using Platelet Rich Fibrin (PRF) for prevention of gingival invaginations following orthodontic extraction space closure

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00038481
Enrollment
20
Registered
2025-12-02
Start date
2023-08-08
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival invaginations. These are pockets of the oral mucosa that can be measured using a periodontal probe and that occur in association with tooth extractions and orthodontic space closure as a consequence of insufficient bone regeneration of the alveolar ridge in the extraction area.

Interventions

Group 1: Tooth extraction-sites in which PRF was placed of patients indicated for orthodontic space closure Group 2: Tooth extraction-sites of patients undergoing orthodontic space-closure treatment w

Sponsors

Universitätsklinikum Bonn, Zentrum für Zahn-, Mund- und Kieferheilkunde, Poliklinik für Kieferorthopädie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
11 Years to 30 Years

Inclusion criteria

Inclusion criteria: - Orthodontic indication for premolar extraction - Written informed consent for treatment and participation in the study provided by the patients and their legal guardians - Patients who are capable of providing the necessary compliance for treatment and who are likely to attend all required study visits

Exclusion criteria

Exclusion criteria: - The patient and/or legal guardian does not provide consent to participate in the study - The patient is unable to understand the scope, significance, and implications of this clinical study - Inability of the patient to provide the level of cooperation necessary for the therapy - Medication (e.g., bisphosphonates), syndromes, or diseases that substantially affect bone or connective tissue metabolism (e.g., cleidocranial dysplasia) - Poor adherence during treatment

Design outcomes

Primary

MeasureTime frame
Incidence and severity of gingival invaginations after orthodontic space closure

Secondary

MeasureTime frame
Temporal changes in the alveolar ridge width at the extraction site

Countries

Germany

Contacts

Public ContactEric Kutschera

Universitätsklinikum Bonn, Zentrum für Zahn-, Mund- und Kieferheilkunde

eric.kutschera@ukbonn.de+4922828722426

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026