A Phenotype-Genotype Association Study Investigating Embolic Stroke of Undetermined Source

A Phenotype-Genotype Association Study Investigating Embolic Stroke of Undetermined Source - PHEGAESUS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038459

Enrollment

5000

Registered

2025-12-04

Start date

2020-12-14

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I63 I64

Interventions

Group 1: Prospective observational study. Laboratory samples taken during routine clinical practice that are no longer needed for routine clinical purposes are stored at two points in time (V1 and V2)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: -written informed consent -imaging confirmed ischemic stroke, but not older than 14 days at admission -available reserve blood sample

Exclusion criteria

Exclusion criteria: not available

Design outcomes

Primary

Measure	Time frame
Primary endpoint: Embolic stroke of undetermined source (ESUS) vs. all other stroke etiologies according to TOAST, determined at the time of discharge. The endpoint is assessed by evaluating the data to be collected in the study protocol. The endpoint was assessed in 10% of patients by two independent stroke experts using randomization.	—

Secondary

Measure	Time frame
Differences in genetic stroke risk variants, clinical parameters, and circulating biomarkers between stroke etiologies	—

Countries

Germany

Contacts

Public ContactJohanna Ernst

Medizinische Hochschule Hannover

ernst.johanna@mh-hannover.de+49 511 532 3580

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jul 15, 2026