Longitudinal Analysis of Coagulation Parameters and Bleeding Risk Before and After ECMO Circuit Exchange in Patients with COVID-19-ARDS: A Retrospective Cohort Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038439

Enrollment

Registered

2025-11-13

Start date

2024-04-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80.03

Interventions

Group 1: Retrospective analysis of all patients who received an ECMO circuit exchange during venovenous extracorporeal membrane oxygenation (vv-ECMO) for COVID-19-associated ARDS.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Admission to the Anaesthesia Intensive Care Unit with COVID-19 associated severe

Exclusion criteria

Exclusion criteria: No ECMO system exchange

Design outcomes

Primary

Measure	Time frame
To determine the inter- and intra-individual variability of D-dimer kinetics over the seven days preceding and following an ECMO system change and to assess the effect of the 'ECMO system change' interaction on D-dimer level trajectories using a linear mixed model. Longitudinal data on coagulation, inflammation and ECMO performance parameters were retrospectively collected from patient charts. All patients who received venovenous ECMO (vvECMO) between 1 August 2020 and 1 May 2022 were included.	—

Measure

Time frame

To determine the inter- and intra-individual variability of D-dimer kinetics over the seven days preceding and following an ECMO system change and to assess the effect of the 'ECMO system change' interaction on D-dimer level trajectories using a linear mixed model. Longitudinal data on coagulation, inflammation and ECMO performance parameters were retrospectively collected from patient charts. All patients who received venovenous ECMO (vvECMO) between 1 August 2020 and 1 May 2022 were included.

—

Secondary

Measure	Time frame
To determine A) whether major bleeding complications occur more frequently in close temporal association with ECMO system changes, and to B) identify predictors of major bleeding based on the trajectory of coagulation, inflammation, and ECMO performance parameters.	—

Countries

Germany

Contacts

Public ContactCarolin Jung

Medizinische Hochschule Hannover

jung.carolin@mh-hannover.de+4917615328127

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026