Retrospective MRI Analysis of Olfactory Bulb Enlargement in Pediatric Patients with Hydrocephalus.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00038428

Enrollment

Registered

2026-06-30

Start date

2025-12-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analysis of the enlargement of the olfactory bulb cavity (Olfactory Bulb Cavity / Olfactory Bulb Ventricle) in pediatric patients with hydrocephalus.

Interventions

Group 1: This retrospective study includes all patients who underwent clinically indicated MRI examinations and were diagnosed with hydrocephalus between 2018 and 2025.

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Inclusion criteria

Inclusion criteria: Patients with pre- and post-operative MRI following ventricular shunt placement Patients with an available thin-slice imaging dataset

Exclusion criteria

Exclusion criteria: No preoperative imaging available prior to shunt placement Tumor or other space-occupying lesions, such as hemorrhage

Design outcomes

Primary

Measure	Time frame
Primary Endpoint: Analysis of the enlargement of the olfactory bulb cavity (Olfactory Bulb Cavity / Olfactory Bulb Ventricle) in pediatric patients with hydrocephalus, comparing pre- and post-decompression MRI examinations. The objective is to determine whether patients with enlarged lateral ventricles also show a proportional enlargement of the olfactory bulb cavity and to what extent this correlates with ventricular volumes. Hypothesis: Enlargement of the olfactory bulb cavity occurs in parallel with ventricular dilation, indicating a potential functional or anatomical connection between the olfactory bulb cavity and the cerebrospinal fluid system. Data collection will be completed once a statistically evaluable number of patients (approximately 30) has been reached.	—

Measure

Time frame

Primary Endpoint: Analysis of the enlargement of the olfactory bulb cavity (Olfactory Bulb Cavity / Olfactory Bulb Ventricle) in pediatric patients with hydrocephalus, comparing pre- and post-decompression MRI examinations. The objective is to determine whether patients with enlarged lateral ventricles also show a proportional enlargement of the olfactory bulb cavity and to what extent this correlates with ventricular volumes. Hypothesis: Enlargement of the olfactory bulb cavity occurs in parallel with ventricular dilation, indicating a potential functional or anatomical connection between the olfactory bulb cavity and the cerebrospinal fluid system. Data collection will be completed once a statistically evaluable number of patients (approximately 30) has been reached.

—

Secondary

Measure	Time frame
Secondary Endpoints: Investigation of the anatomical and imaging correlation between the extent of the olfactory bulb cavity and the degree of ventricular enlargement. Assessment of a possible regression of olfactory bulb cavity enlargement after decompression of the ventricular system. Evaluation of potential age- or development-related differences in olfactory bulb cavity size in children and adolescents.	—

Measure

Time frame

Secondary Endpoints: Investigation of the anatomical and imaging correlation between the extent of the olfactory bulb cavity and the degree of ventricular enlargement. Assessment of a possible regression of olfactory bulb cavity enlargement after decompression of the ventricular system. Evaluation of potential age- or development-related differences in olfactory bulb cavity size in children and adolescents.

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Countries

Germany

Contacts

Public ContactZeynep Bendella

Uniklinik Bonn Neuroradiologie

zeynep.bendella@ukbonn.de0049 228 287 10546

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026