Patients with psoriasis, acne inversa, and a healthy control group.
Conditions
Interventions
Group 1: Adult patients with clinically confirmed psoriasis vulgaris are recruited during special dermatology consultations at Würzburg University Hospital. Disease activity (PASI), oral health (DMFT,
Sponsors
Universitätsklinikum Würzburg, Klinik für Dermatologie, Venerologie und Allergologie
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the study group (psoriasis and acne inversa): • Diagnosis of either psoriasis vulgaris or acne inversa • Capacity to give informed consent • Age between 18 and 60 years Inclusion criteria for the control group • Capacity to give informed consent • Age between 18 and 60 years
Exclusion criteria
Exclusion criteria: Exclusion criteria for study groups (psoriasis and acne inversa) • Incapacity to give consent • Age under 18 and over 60 • Inability to answer the questionnaire (e.g., due to aphasia or organic psychosyndrome) • Contraindications for the planned oral examination (e.g., immunosuppression) • Diagnosis of both psoriasis vulgaris and acne inversa Exclusion criteria for the control group • Age under 18 and over 60 • Existing chronic inflammatory disease • Incapacity to give consent • Immunosuppression • Use of bisphosphonates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is the prevalence of periodontitis. This will be compared between patients with acne inversa or psoriasis (combined as one group) and a healthy control group. The examination is performed by a licensed dentist as part of a dental examination upon enrollment in the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| a. Analysis of whether systemic immunosuppressive or immunomodulatory therapy (DMARDS, NSAIDs, antibiotics, or biologicals) for the two chronic inflammatory skin diseases mentioned above has an impact on the oral health of these patients. Oral health is determined by the DMF index by the examiner (dentist). The b. Analysis of whether patients with moderate to severe psoriasis vulgaris (the severity is determined by a dermatologist) have more frequent oral mucosal changes or poorer oral health than psoriasis vulgaris patients with mild psoriasis vulgaris. c. Analysis of whether patients with moderate to severe acne inversa have more frequent oral mucosal changes or poorer oral health than acne inversa patients with mild acne inversa. d. Analysis of whether the combination of one of the chronic inflammatory skin diseases mentioned and poor oral health has an influence on psychiatric comorbidities such as depression, anxiety disorders, or psychosis. e. Analysis of whether the combination of one of the aforementioned chronic inflammatory skin diseases and poor oral health is associated with certain lifestyle habits, e.g., nicotine, drug, or alcohol abuse. f. Analysis of whether the combination of one of the chronic inflammatory skin diseases mentioned and poor oral health has an impact on patient-specific quality of life (OHIP 14, DLQI). | — |
Countries
Germany
Contacts
Public ContactAstrid Schmieder
Universitätsklinikum Würzburg, Klink für Dermatologie, Venerologie und Allergologie
Outcome results
None listed